羟基肉桂酸类化合物及其衍生物在阿尔茨海默病治疗中的研究进展

Progress of Hydroxycinnamic Acids and Their Derivatives in Alzheimer′s Disease

阿尔茨海默病(Alzheimer′s disease,AD)是一种常见的神经退行性疾病,已经成为不容回避的社会公共卫生问题。羟基肉桂酸类化合物是广泛分布于多种植物中的一类酚酸类化合物,近年来,该类化合物在AD治疗中的作用日益成为研究热点。本文对羟基肉桂酸类化合物在抗AD的作用机制及其结构改造的研究进展进行综述,以期为抗AD药物研发提供新策略。

Alzheimer′s disease is a chronic neurodegenerative disease,which has been recognized as one of the most intractable medical problems with heavy social and economic costs.Hydroxycinnamic acids are phenol derivatives from natural sources and have been found to be potential in the treatment of Alzheimer′s disease recently.In this paper,the newly development of mechanism and structure optimisation of cinnamic acids were summarized.