1例慢性肾功能衰竭患者使用丙戊酸控制癫痫发作不良的案例分析

A Case Analysis of A Patient with Chronic Renal Failure Using Valproic Acid for Poor Seizure Control

临床药师参与1例慢性肾功能衰竭且定期透析的患者使用丙戊酸控制癫痫发作不良的救治。首先利用免疫分析法对患者丙戊酸进行治疗药物浓度测定,再对治疗过程中发现患者丙戊酸血药浓度过低的原因进行分析,同时充分发挥临床药师发现和解决药物相互作用的优势,提高临床药物治疗有效性和安全性。

Clinical pharmacists participated in the treatment process of a case of chronic renal failure and hemodialysis who was treated with valproic acid used in the clinical treatment for poor seizure control.First,use of immune analysis method for patient with valproic acid determination of therapeutic drug monitoring;And analyzed the reasons for the excessively low blood concentration of valproic in the treatment process of this patient.As a member of the clinical treatment team,clinical pharmacists shoud give full play to the advantage of being good at discovering and solving drug interactions and adverse drug reactions,so as to improve the level of clinical drug efficacy and safety.