摘要
超分子化学是一个处于近代化学、材料科学和生命科学交汇点的新兴跨学科的研究领域。其中β-环糊精作为一类典型的超分子结构,其主客体相互作用机制被广泛应用于药物缓释剂的开发。该实验的引进是希望通过核磁共振ROESY和DOSY技术观察β-环糊精与布洛芬的包合作用,帮助学生建立理解有机小分子理论与超分子结构特征的桥梁,并能熟练使用核磁共振谱仪和进行谱图解析。
Supramolecular chemistry is a new interdisciplinary research field at the intersection of modern chemistry, material science and life science. β-cyclodextrin( β-CD) is a kind of typical supramolecular structure, and its host guest interaction mechanism is widely used in the development of drug sustained-release agents. The introduction of this experiment is to observe the inclusion interaction of β-cyclodextrin and Ibuprofen by nuclear magnetic resonance ROESY and DOSY techniques, so as to help students understand the theory of small organic molecules and the structural characteristics of supramolecules, and proficiently use nuclear magnetic resonance spectrometer and spectral analysis.
作者
张春春
付海燕
王晓燕
ZHANG Chunchun;FU Haiyan;WANG Xiaoyan(Analytical&Testing Center,Sichuan University,Chengdu 610064,China;College of Chemistry,Sichuan University,Chengdu 610064,China)
出处
《实验科学与技术》
2022年第4期61-65,共5页
Experiment Science and Technology
基金
四川大学实验技术项目资助(SCU201212)。
关键词
超分子结构
Β-环糊精
核磁共振技术
实验教学
supramolecular structure
β-cyclodextrin
NMR technology
experimental teaching
