肠外致病性大肠杆菌研究

Research on extraintestinal pathogenic Escherichia coli

肠外致病性大肠杆菌(Extraintestinal pathogenic E.coli,ExPEC)是近年来出现的引起人和动物免疫系统受损的主要临床病原体,由不同血清型且不发生交叉反应的菌株引起,部分菌株具有高度耐药性是导致感染严重程度的主要因素之一。对目前ExPEC的主要感染类型、毒力因子以及抵御感染的潜在手段进行了概述。

Extraintestinal pathogenic E.coli(ExPEC)was the main clinical pathogen that had appeared in recent years to cause dam⁃age to the immune system of humans and animals.It consisted of a large number of different serotypes that did not cross-react.The seri⁃ousness of the infection was due to the fact that most of the infecting bacteria were highly antibiotic resistant.The main types of infec⁃tion involved in ExPEC,virulence factors,and potential means to combat the infections were discussed.