阿莫西林+兰索拉唑+克拉霉素联合酪酸梭菌二联活菌对慢性胃炎伴Hp感染患儿血清炎症因子水平的影响

Effect of Amoxicillin,Lansoprazole,Clarithromycin Combined With Clostridium Butyricum on Serum Inflammatory Factors in Children With Chronic Gastritis and HP Infection

目的研究阿莫西林+兰索拉唑+克拉霉素联合酪酸梭菌二联活菌对于慢性胃炎伴幽门螺杆菌(Hp)感染患儿的血清炎症因子以及临床疗效的影响。方法采取随机数表法将80例慢性胃炎伴Hp感染患儿分为对照租与研究组,每组40例,对照组给予阿莫西林+兰索拉唑+克拉霉素的传统三联疗法,研究组在对照组基础上配合酪酸梭菌二联活菌治疗,治疗疗程为14d。利用胃肠道症状评分(GSRS)对患儿消化道症状进行评价并分析比较两组Hp根除率、血清炎症因子水平[超敏C反应蛋白(CRP)、白介素-6(IL-6)、白介素-8(IL-8)]以及胃肠不良反应发生情况。结果治疗后研究组患儿GSRS评分显著低于对照组(P<0.05)。研究组Hp根除率为87.5%,显著高于对照组的67.5%(P<0.05)。研究组患儿治疗后的CRP、IL-6、IL-8指标水平均低于对照组(P<0.05)。研究组患儿治疗后消化系统不良反应发生率为17.5%,低于对照组的52.5%(P<0.05)。结论应用阿莫西林+兰索拉唑+克拉霉素联合酪酸梭菌二联活菌治疗小儿慢性胃炎伴Hp感染可以有效缓解慢性胃炎症状,提高Hp根除率,降低血清炎症因子水平,还能减少药物不良反应。

Objective To study the effect of amoxicillin,lansoprazole,clarithromycin combined with clostridium butyricum on serum inflammatory factors in children with chronic gastritis and HP infection.Methods A total of 80 children with chronic gastritis complicated with HP infection were randomly divided into control group and study group,40 cases in each group.The control group was treated with the traditional triple therapy of amoxicillin+lansoprazole+clarithromycin,and the study group was given the treatment of clostridium butyricum on the basis of the control group.The treatment course was 14 days.Gastrointestinal symptom rating score(GSRS)was used to evaluate the gastrointestinal symptoms of the children,and the HP eradication rate,serum inflammatory factor levels[high sensitivity C-reactive protein(CRP),interleukin-6(IL-6),interleukin-8(IL-8)]and gastrointestinal adverse reactions of the two groups were analyzed and compared.Results After treatment,the GSRS score of the study group was significantly lower than that of the control group(P<0.05).The eradication rate of HP in the study group was 87.5%,which was significantly higher than that of the control group(67.5%)(P<0.05).The levels of CRP,IL-6 and IL-8 in the study group after treatment were lower than those in the control group(P<0.05).The incidence of digestive system adverse reactions in the study group was 17.5%,which was lower than that of the control group(52.5%)(P<0.05).Conclusion The application of amoxicillin,lansoprazole,clarithromycin combined with clostridium butyricum in the treatment of children with chronic gastritis with HP infection can effectively alleviate the symptoms of chronic gastritis,improve the eradication rate of HP,reduce the level of serum inflammatory factors,and reduce adverse drug reactions.