丙硫氧嘧啶治疗甲状腺功能亢进症疗效及其安全性分析

Efficacy and Safety Analysis of Propylthiouracil in the Treatment of Hyperthyroidism

目的探讨丙硫氧嘧啶治疗甲状腺功能亢进症疗效及其安全性。方法连续收集分泌科门诊或在内分泌科病房住院,明确诊断为甲亢的患者共120例,随机分为研究组和对照组各60例。两组患者均给予一般治疗,对照组加用甲巯咪唑,研究组加用丙硫氧嘧啶治疗。比较两组治疗效果、甲状腺功能相关指标以及药物不良反应。结果丙硫氧嘧啶治疗后甲亢患者高代谢相关症状和体征得到显著改善,症状减轻概率明显大于对照组;此外,观察组患者血清中FT3、FT4、TPOAb和TgAb指标均低于对照组,而TSH指标高于对照组(P<0.05);用药过程监测观察组共有3例患者出现胃肠道不良反应,停药后自行好转,较对照组不良反应发生率显著降低(P<0.05)。结论对于甲状腺功能亢进患者,应用丙硫氧嘧啶治疗临床效果好,高代谢症状减轻明显,同时还能显著改善甲状腺功能,不良反应少,安全性高,是治疗甲亢的优选药物。

Objective To investigate the efficacy and safety of propanthiouracil in the treatment of hyperthyroidism.Methods A total of 120 patients with hyperthyroidism who were admitted to the outpatient department of endocrinology or hospitalized in the ward of endocrinology department were collected and randomly divided into study group and control group,60 patients in each group.Methimazole was added to the control group and propyl thiouracil was added to the study group.The treatment effect,thyroid function related indexes and adverse drug reactions were compared between the two groups.Results The hypermetabolism-related symptoms and signs of hyperthyroidism patients were significantly improved after treatment with propylthiouracil,and the probability of symptom reduction was significantly higher than that of control group.In addition,serum FT3,FT4,TPOAb and TgAb in observation group were against control group,while TSH was higher than control group(P<0.05).A total of 3 patients in the observation group had gastrointestinal adverse reactions during medication,which improved spontaneously after drug withdrawal,and the incidence of adverse reactions was significantly lower than that in the control group(P<0.05).Conclusion For patients with hyperthyroidism,the application of propylthiouracil in the treatment of clinical effect is good,the symptoms of hypermetabolism are significantly reduced,but also significantly improve the thyroid function,less adverse reactions,high safety,is the preferred drug for the treatment of hyperthyroidism.