胃、十二指肠低分化腺癌诱发黑棘皮病1例

Acanthosis Nigricans Induced by Poorly Differentiated Adenocarcinoma of the Stomach and Duodenum:A Case Report

患者男,24岁,纳差伴全身皱褶部位皮肤突发色素加深、疣状增生2个月。皮肤科情况:全身皱褶部位皮肤可见弥漫性色素沉着,皮肤呈天鹅绒样增厚,以颈部、腋下、会阴部为重,对称分布。皮损组织病理示:符合黑棘皮病。胃镜下见胃窦、胃体、十二指肠球部局部病灶,病灶组织病理示:低分化腺癌。体重指数(body mass index,BMI)23.72 kg/m^(2),实验室检查无血糖、肾上腺、垂体功能及自身免疫抗体等异常。诊断:胃、十二指肠低分化腺癌诱发黑棘皮病。

A 24-year-old male had poor appetite accompanied by sudden deepening of skin pigmentation and verrucous hyperplasia in the folds of the whole body for 2 months.Dermatological examination showed that diffuse pigmentation could be seen in the skin of the folds of the whole body,with velvety thickening of the skin,the neck,armpits,and perineum,were more serious,and with symmetrical distribution.Histopathology of the skin lesions showed that it was consistent with acanthosis nigricans.Under gastroscope,local lesions in the gastric antrum,gastric body,and duodenal bulb were seen.Histopathological examination revealed poorly differentiated adenocarcinoma.Body Mass Index(BMI)of the patient was 23.72 kg/m^(2),and laboratory examination showed no abnormalities in blood sugar,adrenal gland,pituitary function and autoimmune antibodies.The diagnosis of acanthosis nigricans induced by poorly differentiated adenocarcinoma of the stomach and duodenum was made.