血清NT-proBNP与IL-6表达水平对川崎病患儿预后的影响

Effect of expression levels of serum NT-proBNP and IL-6 on the prognosis of children with Kawasaki disease

目的:通过观察血清氨基末端脑钠肽前体(NT-proBNP)与白细胞介素-6(IL-6)表达水平从而分析对川崎病(KD)患儿预后的影响。方法:选取本院2017年6月~2020年6月收治的KD患儿80例设为研究观察组,通过心动图检测冠状动脉(冠脉)受损44例设为A组,未受损36例设为B组;选取同期本院仅因上呼吸道感染导致发热进行就诊的患儿80例设为对照组。比较观察组和对照组患儿血清NT-proBNP与IL-6水平;A组和B组患儿心室相关指标以及血清NT-proBNP与IL-6水平的变化。结果:观察组血清NT-proBNP与IL-6水平较对照组显著升高,差异具有统计学意义(P<0.05);B组血清NT-proBNP与IL-6水平较A组显著减少,A组心室相关指标较B组显著降低,差异具有统计学意义(P<0.05)。结论:KD患儿血清里NT-proBNP与IL-6水平可反映患儿冠脉损伤程度,在临床诊断中参考其水平变化,有助于KD的及早诊断,从而实施治疗有效改善预后。

Objective:To analyze the prognosis of children with Kawasaki disease(KD)by observing the expression levels of serum N-terminal pro-brain natriuretic peptide(NT-proBNP)and interleukin-6(IL-6).Methods:80 children with KD who were treated in the hospital between June 2017 and June 2020 were selected as the study observation group.44 cases of coronary artery damage detected by electrocardiography were selected as the group A,and 36 cases without damage were set as the group B.80 children admitted to the hospital due to fever cased by upper respiratory tract infection during the same period were included as the control group.The levels of serum NTproBNP and IL-6 were compared between the observation group and the control group.The changes in ventricular related indexes and serum NT-proBNP and IL-6 of children were compared between the group A and the group B.Results:The levels of serum NTproBNP and IL-6 in the observation group were significantly higher than those in the control group(P<0.05).Serum NT-proBNP and IL-6 levels in the group B were significantly lower compared to the group A,and the ventricular related indexes in the group A were significantly lower than those in the group B(P<0.05).Conclusion:Serum levels of NT-proBNP and IL-6 in children with KD can reflect the degree of coronary artery damage in children.Reference to changes in the levels in clinical diagnosis is helpful for early diagnosis of KD,so that treatment can effectively improve the prognosis.