香菊胶囊联合桉柠蒎肠溶软胶囊治疗慢性鼻窦炎患者的效果

Effects of Xiangju capsules combined with Eucalyptol,Limonene and Pinene enteric capsules in the treatment of patients with chronic sinusitis

目的:观察香菊胶囊联合桉柠蒎肠溶软胶囊治疗慢性鼻窦炎患者的效果。方法:选取2017年5月至2019年11月该院收治的116例慢性鼻窦炎患者进行前瞻性研究,按随机数字表法分为观察组与对照组各58例,对照组采用桉柠蒎肠溶软胶囊,观察组在对照组基础上联合香菊胶囊治疗,比较两组疗效、治疗前后疼痛数字评分法(NRS)评分、血清炎性因子[C反应蛋白(CRP)、白细胞介素-17(IL-17)]水平,以及不良反应发生率。结果:观察组治疗总有效率为96.55%,高于对照组的74.14%,差异有统计学意义(P<0.05);治疗后,两组面部疼痛、头痛NRS评分均低于治疗前,且观察组低于对照组,差异有统计学意义(P<0.05);治疗后,两组CRP、IL-17水平均低于治疗前,且观察组低于对照组,差异有统计学意义(P<0.05);观察组不良反应发生率为3.45%,低于对照组的13.79%,差异有统计学意义(P<0.05)。结论:香菊胶囊联合桉柠蒎肠溶软胶囊治疗慢性鼻窦炎患者可提高治疗总有效率,降低NRS评分、血清炎性因子水平和不良反应发生率,优于单纯桉柠蒎肠溶软胶囊治疗效果。

Objective:To observe effects of Xiangju capsules combined with Eucalyptol,Limonene and Pinene enteric capsules in the treatment of patients with chronic sinusitis.Methods:116 patients with chronic rhinosinusitis admitted to our hospital from May 2017 to November 2019 were selected as the research objects,and were divided into observation group and control group according to the random number table method,58 cases in each.The control group was treated with Eucalyptol,Limonene and Pinene enteric capsules,while the observation group was treated with Xiangju capsules on the basis of that of the control group.The treatment effects,the digital pain score(NRS),the serum inflammatory factor index [C-reactive protein(CRP),interleukin-17(IL-17)] levels before and after treatment,and the incidence of adverse reactions were compared between the two groups.Results:The total effective rate of the observation group was 96.55%,which was higher than 74.14% of the control group,and the difference was statistically significant(P<0.05).After the treatment,the NRS scores of facial pain and headache in the two groups were lower than those before the treatment,those of the observation group were lower than those of the control group,and the differences were statistically significant(P<0.05).After the treatment,the levels of CRP and IL-17 in the two groups were lower than those before the treatment,those of the observation group were lower than those of the control group,and the differences were statistically significant(P<0.05).Further,the incidence of adverse reactions in the observation group was 3.45%,which was lower than 13.79% in the control group,and the difference was statistically significant(P<0.05).Conclusions:Xiangju capsules combined with Eucalyptol,Limonene and Pinene enteric capsule in the treatment of the patients with chronic sinusitis can improve the total effective rate of treatment and reduce the NRS score,the serum inflammatory factor levels and the incidence of adverse reactions.Moreover,it is superior to single Eucalyptol,Limonene and Pinene enteric capsules.