血清IL-34、TGF-β1和TGF-β2水平对强直性脊柱炎的诊断价值

Values of serum IL-34,TGF-β1 and TGF-β2 levels in diagnosis of ankylosing spondylitis

目的:探讨血清白细胞介素-34(IL-34)、转化生长因子β_(1)(TGF-β_(1))和转化生长因子β_(2)(TGF-β_(2))水平对强直性脊柱炎(AS)的诊断价值。方法:回顾性分析2019年1月至2020年1月该院收治的62例AS患者(AS组)、62例类风湿关节炎(RA)患者(RA组)、另取50名健康体检者(对照组)的临床资料。比较三组受试者及不同病变程度AS患者的血清IL-34、TGF-β_(1)和TGF-β_(2)水平。采用受试者工作特征(ROC)曲线分析血清IL-34、TGF-β_(1)和TGF-β_(2)单项及联合检测对AS的诊断价值。结果:AS组、RA组的血清IL-34、TGF-β_(1)和TGF-β_(2)水平均明显高于对照组,且AS组IL-34、TGF-β_(1)、TGF-β_(2)水平均高于RA组,差异有统计学意义(P<0.05);骨关节、附着点病变数≥3个的AS患者血清IL-34、TGF-β_(1)和TGF-β_(2)水平均高于骨关节、附着点病变数<3个的AS患者,差异有统计学意义(P<0.05);ROC曲线分析显示,血清IL-34、TGF-β_(1)和TGF-β_(2)联合检测诊断AS的AUC为0.975,高于单一指标检测。结论:AS患者血清IL-34、TGF-β_(1)和TGF-β_(2)水平高于健康人和RA患者,且与病情程度呈正比,联合检测对AS的诊断价值高于单一指标检测。

Objective:To investigate values of serum levels of interleukin-34(IL-34),transforming growth factorβ_(1)(TGF-β_(1))and transforming growth factorβ_(2)(TGF-β_(2))in diagnosis of ankylosing spondylitis(AS).Methods:The clinical data of 62 AS patients(AS group),62 rheumatoid arthritis(RA)patients(RA group)and 50 healthy subjects(control group)admitted to this hospital from January 2019 to January 2020 were retrospectively analyzed.The serum levels of IL-34,TGF-β_(1) and TGF-β_(2) were compared among the three groups and among the AS patients with different degrees of lesions.The receiver operating characteristic curve(ROC)was used to analyze the values of single serum IL-34,single TGF-β_(1) and single TGF-β_(2) and combined detection in the diagnosis of AS.Results:The levels of serum IL-34,TGF-β_(1) and TGF-β_(2) in the AS group and the RA group were significantly higher than those in the control group;the levels of IL-34,TGF-β_(1) and TGF-β_(2) in the AS group were higher than those in the RA group;and the differences were statistically significant(P<0.05).The serum levels of IL-34,TGF-β_(1) and TGF-β_(2) in the AS patients with joint attachment point lesion≥3 were higher than those in the AS patients with joint attachment point lesion<3,and the difference was statistically significant(P<0.05).The ROC curve showed that the AUC of the combined detection of serum IL-34,TGF-β_(1) and TGF-β_(2) in the diagnosis of AS was 0.975,which was higher than that of the single index detection.Conclusions:The serum levels of IL-34,TGF-β_(1) and TGF-β_(2) in the AS patients are higher than those in the healthy people and the RA patients,and are proportional to the severity of the disease.Further,the diagnostic value of combined detection for AS is higher than that of single index detection.