醒脑通络开窍汤联合丁苯酞注射液治疗急性缺血性卒中患者的效果

Effects of Xingnao Tongluo Kaiqiao decoction combined with Butylphthalide injection in treatment of patients with acute ischemic stroke

目的:观察醒脑通络开窍汤联合丁苯酞注射液治疗急性缺血性卒中患者的效果。方法:回顾性分析2019年1月至2021年1月该院收治的60例急性缺血性卒中患者的临床资料,根据治疗方法不同将其分为对照组与观察组各30例。对照组采用丁苯酞注射液治疗,观察组在对照组基础上联合醒脑通络开窍汤治疗,比较两组临床疗效、治疗前后中医证候积分、神经功能缺损程度[美国国立卫生研究院卒中量表(NIHSS)]评分、血液流变学指标[血浆黏度(PV)、全血黏度(WBV)]水平和不良反应发生率。结果:观察组治疗总有效率为96.67%(29/30),高于对照组的73.33%(22/30),差异有统计学意义(P<0.05);治疗后,观察组中医证候积分低于对照组,差异有统计学意义(P<0.05);治疗后,观察组NIHSS评分低于对照组,差异有统计学意义(P<0.05);治疗后,观察组WBV、PV水平均低于对照组,差异有统计学意义(P<0.05);两组均未出现明显不良反应。结论:醒脑通络开窍汤联合丁苯酞注射液治疗急性缺血性卒中患者可提高治疗总有效率,降低中医证候积分、NIHSS评分和血液流变学指标水平,其效果优于单纯丁苯酞治疗。

Objective:To observe effects of Xingnao Henan Tongluo Kaiqiao decoction combined with Butylphthalide injection in treatment of patients with acute ischemic stroke.Methods:The clinical data of 60 patients with acute ischemic stroke admitted to this hospital from January 2019 to January 2021 were retrospectively analyzed.According to different treatment methods,they were divided into control group and observation group,30 cases in each.The control group was treated with Butylphthalide injection,while the observation group was treated with Xingnao Tongluo Kaiqiao decoction on the basis of that of the control group.The clinical effects,the TCM syndrome scores before and after treatment,the the degree of neurological deficit[national institutes of health stroke scale(NIHSS)]score,the hemorheology index levels[plasma viscosity(PV),whole blood viscosity(WBV)],and incidence of adverse reactions were compared between the two groups.Results:The total effective rate of treatment in the observation group was 96.67%(29/30),which was higher than the control group of 73.33%(22/30),and the difference was statistically significant(P<0.05).After the treatment,the TCM syndrome score in the observation group was lower than that in the control group,and the difference was statistically significant(P<0.05).After the treatment,the NIHSS score of the observation group was lower than that of the control group,and the difference was statistically significant(P<0.05).After the treatment,the levels of WBV and PV in the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05).However,there were no obvious adverse reactions in the two groups.Conclusions:Xingnao Tongluo Kaiqiao decoction combined with Butylphthalide injection in the treatment of the patients with acute ischemic stroke can improve the total effective rate of treatment,and reduce the TCM syndrome score,the NIHSS score and the hemorheology index levels.Moreover,it is superior to single Butylphthalide injection treatment.