蛋白质S-亚硝基化与消化系统肿瘤关系的研究进展

Advances on the Relationship between Protein S-nitrosylation and Digestive System Tumors

S-亚硝基化修饰是由高浓度一氧化氮(NO)对蛋白质进行选择性的可逆性翻译后修饰,与多种细胞过程和组织稳态有关。大多消化系统肿瘤与炎症发展相互作用,炎症状态下机体诱导大量NO产生,NO具有使底物蛋白S-亚硝基化修饰的作用。目前已发现多种癌组织中蛋白的S-亚硝基化表达异常,回顾国内外相关研究,S-亚硝基化与肿瘤发生发展关系已成为当下研究热点。简述了蛋白质S-亚硝基化失衡在不同消化系统肿瘤中发生发展以及治疗中的作用机制,得出在不同消化系统肿瘤中S-亚硝基化失衡可以通过不同蛋白质的S-亚硝基化促进或抑制肿瘤的发展,旨在挖掘消化系统肿瘤中S-亚硝基化水平的治疗潜力。

S-nitrosylation modification is a selective and reversible post-translational modification of protein by high concentration of nitric oxide(NO),which is related to a variety of cellular processes and tissue homeostasis.Most digestive system tumors interact with the development of inflammation.The body induces a great deal of NO in an inflammatory state and NO can modify the substrate protein S-nitrosylation.At present,it has been found that the expression of S-nitrosylation of proteins in a variety of cancer tissues is abnormal.Relevant studies at home and abroad show that the relationship between S-nitrosylation and tumor occurrence and development has become a current research focus.By briefly describing the mechanism of protein S-nitrosylation imbalance in the occurrence and development of different digestive system tumors and treatments,this review concludes that S-nitrosylation imbalance in different digestive system tumors can promote or inhibit the development of tumors through the Snitrosylation of different proteins and aims to tap the therapeutic potential of S-nitrosylation level in digestive system tumors.