计算机体层血管成像联合IL-6、TNF-α水平检测对颅内动脉瘤的诊断价值

Diagnostic value of computed tomography angiography combined with IL-6 and TNF-α in intracranial aneurysms

目的 探讨采用计算机体层血管成像(CTA)与白介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)联合检测对颅内动脉瘤的诊断鉴别价值。方法 选取本院2019年3月~2022年3月收治的108例颅内动脉瘤疑似病例,采用CTA联合IL-6、TNF-α检测分析其对颅内动脉瘤的诊断价值。结果 108例疑似患者经数字减影血管造影检测发现93例确诊为颅内动脉瘤,CTA诊断为87例,CTA诊断的Kappa值为0.669,准确性为90.74%,敏感度为0.914,特异性为0.867;颅内动脉瘤患者机体血清IL-6、TNF-α水平高于非颅内动脉瘤患者(P<0.05);Spearman相关性分析显示:IL-6、TNF-α与患者颅内动脉瘤的发生呈正相关关系(r=0.377、0.453,P<0.05);ROC曲线显示,CTA与IL-6、TNF-α联合诊断指标曲线下面积为0.974,高于各单项指标曲线下面积(P<0.05)。结论 CTA联合IL-6、TNF-α检测对颅内动脉瘤具有较高的诊断价值。

Objective To evaluate the diagnostic value of computed tomography angiography(CTA) combined with interleukin(IL-6) and tumor necrosis factor-α(TNF-α) in intracranial aneurysms.Methods A total of 108 suspected cases of intracranial aneurysm admitted to our hospital from March 2019 to March 2022 were selected.The diagnostic value of CTA combined with IL-6 and TNF-α were analyzed.Results Among 108 suspected patients,93 were diagnosed as intracranial aneurysm by DSA and 87 were diagnosed by CTA.The Kappa value of CTA was 0.669,accuracy was 90.74%,sensitivity was 0.914 and specificity was 0.867.The serum levels of IL-6 and TNF-α in patients with intracranial aneurysm were significantly higher than those in patients without intracranial aneurysm(P<0.05).Spearman correlation analysis showed that IL-6 and TNF-α were positively correlated with the occurrence of intracranial aneurysm(r=0.377,0.453,P<0.05).ROC curve showed that the area under the curve of CTA combined with IL-6 and TNF-α was 0.974,which was significantly higher than the area under the curve of each single index(P<0.05).Conclusion CTA combined with IL-6 and TNF-α has high diagnostic value for intracranial aneurysm.