血清同型半胱氨酸水平、胱抑素C水平与老年卒中后抑郁的相关性分析

Correlation between serum homocysteine level,cystatin C level and depression in the elderly patients with post-stroke depression

目的探究老年卒中后抑郁与血清同型半胱氨酸(Hcy)水平、胱抑素C(CysC)水平的相关性。方法选取本院2018年12月1日~2020年1月1日住院并确诊为急性缺血性脑卒中老年患者121例,根据汉密尔顿抑郁量表(HAMD)对患者抑郁症状进行评估,依据是否抑郁进行分组,66例卒中后抑郁患者为观察组,55例卒中后无抑郁患者为对照组,分析两组患者性别、年龄等一般资料和患者血清Hcy水平、CysC水平,采用二元Logistic回归分析卒中后抑郁与血清Hcy水平、CysC水平的相关性。结果两组患者年龄、性别、糖尿病史、高血压病史等一般资料比较,差异无统计学意义(P>0.05);两组之间血清Hcy、CysC水平比较差异明显,且观察组血清Hcy、CysC水平明显高于对照组(P<0.05);采用二元Logistic回归分析,血清Hcy、CysC水平与卒中后抑郁呈正相关(P<0.05)。结论脑卒中患者血清Hcy、CysC水平增加了患者发生卒中后抑郁的风险,临床须密切关注脑卒中患者血清Hcy、CysC水平,以减少卒中后抑郁的发生。

Objective To explore the correlation between post-stroke depression and serum homocysteine(Hcy level and cystatin C(CysC)level in the elderly.Methods 121 elderly patients with acute cerebral ischemic stroke in our hospital from December 1,2018 to January 1,2020 were selected.Using Hamilton depression rating scale(HAMD)to evaluate the level of patients with depressive symptoms,66 cases of patients with poststroke depression as the observation group,55 patients with poststroke depression as the control group.General information,such as gender and age,and serum Hcy level and CysC level of patients in the two groups were analyzed,and the correlation between post-stroke depression and serum Hcy level and CysC level was analyzed by Binary Logistic regression.Results There was no significant difference in age,gender,diabetes history,hypertension history and other general information between 2 groups(P>0.05).The serum Hcy and CysC levels in the observation group were significantly higher than those in the control group(P<0.05).By Binary logistic regression analysis,serum Hcy and CysC levels were positively correlated with poststroke depression(P<0.05).Conclusion Serum Hcy and CysC levels increased the risk of post-stroke depression in stroke patients.Clinical attention should be paid to serum Hcy and CysC levels in stroke patients to reduce the occurrence of poststroke depression.