摘要
We present for the first time,to the best of our knowledge,a needle probe for photoacoustic viscoelasticity(PAVE)measurements at a depth of 1 cm below the sample surface.The probe uses a gradient index rod lens,encased within a side-facing needle(0.7 mm outer diameter),to direct excitation light(532 nm)and detection light(1325 nm)focused on the sample,collecting and directing the returned detection light in a spectral domain low coherence interferometry system,which allows for obtaining optical phase differences due to photoacoustic oscillations.The feasibility of needle probe for PAVE depth characterization was investigated on gelatin phantoms and in vitro biological tissues.The experimental results in an in vivo animal model predict the great potential of this technique for in vivo tumor boundary detection.
作者
Daoqian Yang
Zhongjiang Chen
Da Xing
杨道乾;陈重江;邢达(MOE Key Laboratory of Laser Life Science&Institute of Laser Life Science,College of Biophotonics,South China Normal University,Guangzhou 510631,China;Guangdong Provincial Key Laboratory of Laser Life Science,College of Biophotonics,South China Normal University,Guangzhou 510631,China;Department of Ophthalmology and Optometry,School of Medical Technology and Engineering,Fujian Medical University,Fuzhou 350004,China)
基金
This work was supported by the National Natural Science Foundation of China(Nos.61805085 and 61705068)
the Science and Technology Planning Project of Guangdong Province,China(No.2018A030310519)
the Guangzhou Science and Technology Plan Project(No.201904010321)
the Natural Science Foundation of Fujian Province(No.2021J01813)
the Science and Technology Program of Guangzhou(No.2019050001).
