基于细胞焦亡理论探讨中医药防治类风湿关节炎研究进展

Traditional Chinese Medicine in Prevention and Treatment of Rheumatoid Arthritis Based on Pyroptosis Theory:A Review

细胞焦亡属于一种新发现的程序性细胞死亡,是机体重要的天然免疫反应,在抗击感染中具有重要作用。研究表明,细胞焦亡在类风湿关节炎的发生发展中扮演着重要的角色。中医药在防治类风湿关节炎中具有独特优势,如何利用细胞焦亡理论指导中医药有效防治类风湿关节炎是该领域新的研究热点。该文从细胞焦亡理论概述、作用机制和信号通路、在类风湿关节炎治疗中的应用及基于细胞焦亡理论的中药活性研究等方面进行了整理和总结,发现细胞焦亡的发生与胱天蛋白酶-1(Caspase-1)依赖的经典型炎症小体通路和Caspase-1非依赖的非经典型炎症小体通路有关,细胞焦亡在类风湿关节炎的发生发展、治疗中都发挥着重要的调控作用,这将为类风湿关节炎的治疗提供了新的策略。同时对中药干预细胞焦亡发挥生物活性的整理发现,诸如苗族药验方四大血、独活寄生汤、石榴苷、芍药苷单体衍生物等多种中药有效成分,均能够通过调节细胞焦亡发挥抗风湿等生物活性,为细胞焦亡理论的深入研究及指导中医药防治类风湿关节炎提供理论了依据和研究思路。

Pyroptosis is a newly discovered programmed cell death.It is an important natural immune response and has obvious anti-infection function.Studies have shown that pyroptosis plays an important role in the occurrence and development of rheumatoid arthritis.Traditional Chinese medicine(TCM)has unique advantages in the prevention and treatment of rheumatoid arthritis.How to guide TCM to effectively prevent and treat rheumatoid arthritis using pyroptosis theory is a new research hotspot in this field.This paper discussed the overview of pyroptosis theory,its mechanism,signal pathway,and application in the treatment of rheumatoid arthritis as well as the research on the activity of TCM based on pyroptosis theory.It was found that the occurrence of pyroptosis was related to Caspase-1-dependent classical inflammatory body pathway and Caspase-1-independent non classical inflammatory body pathway,and pyroptosis produced distinct regulatory effect on the occurrence,development and treatment of rheumatoid arthritis,which would provide a new strategy for the treatment of rheumatoid arthritis.Additionally,TCM recipes such as Miao ethnomedicine prescription Sidaxue and Duhuo Jishengtang,and a variety of effective components such as punicalagin and paeoniflorin monomer derivatives exerted anti-rheumatic and other biological activities by regulating pyroptosis.This provided a theoretical basis and research ideas for the in-depth study of pyroptosis theory and guiding the prevention and treatment of rheumatoid arthritis with TCM.