内脏脂肪组织与结直肠癌发病风险及预后关系研究进展

Advances in the association between visceral adipose tissue and risk and prognosis of colorectal cancer

内脏脂肪组织比皮下脂肪组织有更高的代谢活性,促进胰岛素抵抗和分泌促炎细胞因子,可视为一个内分泌和旁分泌器官。大量的内脏脂肪组织阻挡手术视野,促进胰岛素抵抗和炎症通路,直接或间接影响结直肠癌的发生风险、术后并发症发生率、生存时间以及辅助治疗疗效。外科医生通过健康体检和术前检查评估内脏脂肪组织数量,有助于向病人提供更适合的预防建议、手术规划以及预后预测。

Visceral adipose tissue has higher metabolic activity than subcutaneous adipose tissue. Visceral adipose tissue promotes insulin resistance and secretes proinflammatory cytokines, which can be regarded as an endocrine and paracrine organ. A large amount of visceral adipose tissue blocks the surgical field, and promotes insulin resistance and inflammatory pathways, which affects the risk of colorectal cancer, the incidence of postoperative complications, survival time and the efficacy of adjuvant therapy, directly or indirectly. It helps surgeons provide more appropriate preventive advice, surgical planning and prognosis prediction by evaluating the amount of visceral adipose tissue from physical examination and preoperative examination.