RNF11的特性以及其在恶性肿瘤中的研究进展

Characterization of RNF11 and Progress of It’s Research in Malignant Tumors

环指蛋白家族成员参与调控多种细胞活动,是疾病发展过程中的关键调节因子。环指蛋白11(ring finger protein 11,RNF11)属于环指蛋白家族,是一个含154个氨基酸残基的蛋白质,已广泛引起人们的关注。RNF11在细胞信号转导和转录因子调节中发挥重要作用,尤其在EGFR、TGF-β和NF-κB通路中发挥调节作用,与恶性肿瘤的发生发展密切相关。尽管有研究表明RNF11在人类前列腺癌、结肠癌和浸润性乳腺癌中过度表达,但是它作为肿瘤生长抑制或促进剂发挥作用仍然存在争议。该文主要综述RNF11的结构、主要生物学功能以及它在恶性肿瘤发生和转移中的作用,为进一步研究相关疾病的治疗方法与靶向药物提供理论依据。

Members of the ring finger protein family are involved in the regulation of a variety of cellular activities and are key regulators in the development of disease.RNF11 (ring finger protein 11),a 154-amino acid residue protein,is a member of the ring finger family of proteins that has attracted widespread interest.RNF11 plays an important role in cell signaling and transcription factor regulation,particularly in the EGFR,TGF-β and NF-κB pathways,and is closely associated with the development of malignant tumors.It is closely associated with the development of malignant tumors.Although RNF11 has been shown to be overexpressed in human prostate,colon and invasive breast cancers,its role as a tumor growth suppressor or promoter remains controversial.This paper reviews the structure and main biological functions of RNF11 and its role in malignant tumorigenesis and metastasis,and provides a theoretical basis for further research on therapeutic method and targeted drugs for related diseases.