巨噬细胞极性重塑在疾病和组织稳态中的作用

Role of Macrophage Plasticity and Polarization in Tissue Homeostasis and Disease

巨噬细胞是最重要的固有免疫细胞之一,极化和可塑性是其显著特征。这使巨噬细胞在应对微环境信号和刺激时可以极化为与局部环境相匹配的特征、表型和功能,从而更准确地调节组织稳态,极化和可塑性失调往往与多种疾病的发生、发展密切相关。然而巨噬细胞极性和可塑性调节在多种生理、病理过程中的作用还不十分清楚,有待梳理总结。因此该文以感染、炎症、肿瘤、慢性病等病理过程和组织修复、衰老和妊娠等正常生理过程为切入点,阐述巨噬细胞极性重塑在其中的关键作用和特征性分子,从新的维度描绘巨噬细胞极性重塑在健康和疾病发生中的全景图,旨在明确巨噬细胞极性重塑的全部谱系分子,揭示极性重塑的信号网络和解析极性重塑的分子机制是该领域未来工作的热点,该文有望以巨噬细胞极性重塑为核心开发一系列药物和干预手段,为感染、炎症、肿瘤、慢性病的治疗提供新策略。

Macrophages are one of the most important innate immune cells,the polarization and plasticity are their distinguishing characteristics.This allows macrophages to respond accurately to local stimulates and ligands,and obtain characteristics and functions that match the local microenvironment,to properly participate in the regulation of tissue homeostasis.However,the disorder of polarization and plasticity is also closely related to diseases.The role of macrophage polarity and plasticity regulation in a variety of physiological and pathological processes is still unclear and needs to be sorted out and summarized.Therefore,this review uses pathological processes such as infection,inflammation,tumors,and chronic diseases,as well as normal physiological processes such as tissue repair,aging,and pregnancy to discuss the key role of macrophage polarization and plasticity,in tissue homeostasis and disease.This study aims to describe the overall picture of macrophage polarization and plasticity in health and disease from a new dimension.Depicting the panorama of macrophage polarity remodeling in health and disease.Aiming to identify molecules of multiple lineages of polarity remodeling in macrophages.Unraveling the signaling network and mechanism of macrophage differentiation.Aims to develop a range of drugs and interventions to provide new strategies for the treatment of infections,inflammation,tumors and chronic diseases.