钠-葡萄糖协同转运蛋白2抑制剂的心血管保护机制及临床研究进展

Mechanisms and clinical research of cardio-protective effects of sodium-glucose cotransporter 2 inhibitors

除了降糖作用,钠-葡萄糖协同转运蛋白2抑制剂还有利尿利钠、减轻心脏负荷、改善心肌能量代谢和功能、改善血管内皮功能等心血管保护作用。近年来,多项大规模随机对照试验结果也证实,此类药物除延缓慢性肾脏病进展,还可显著降低动脉粥样硬化事件、心力衰竭住院、心血管和总体死亡率。

Sodium-glucose cotransporter 2 inhibitor as a new hypoglycemic drug is available in Chinese market.In addition to its hypoglycemic effect,it has effect of cardiovascular protection,such as diuresis and natriuresis,which can relieve heart load,improve myocardial energy metabolism and vascular endothelial function.In recent years,several large-scale randomized controlled trials have also confirmed that such drugs can significantly reduce the risk of atherosclerotic events,heart failure hospitalization,cardiovascular and total mortality,and delay the progression of chronic kidney disease.