脂代谢异常与糖尿病肾脏疾病关系与机制研究进展

Research progress on relationship and mechanism between abnormal lipid metabolism and diabetic kidney disease

糖尿病肾脏疾病(diabetic kidney disease,DKD)是慢性肾脏病(chronic kidney disease,CKD)及终末期肾病(end-stage renal disease,ESRD)最常见的原因,而CKD与血脂异常(dyslipidemia)和脂质异位沉积(ectopic lipid deposition,ELD)关系密切。既往研究显示,高脂血症(hyperlipemia)可导致CKD的发生发展,对于DKD亦是如此。调脂类药物可改善2型糖尿病(type 2 diabetes mellitus,T2DM)患者肾脏预后。高血糖(hyperglycemia)、高三酰甘油血症(hypertriglyceridemia)和低高密度脂蛋白胆固醇血症(low high density lipoprotein-cholesterol)等因素可能在DKD发生发展中起着重要作用。故现对脂代谢异常与DKD的关系进行探讨,并分析DKD脂质性肾损伤的潜在机制,旨在为临床诊治提供一定参考。

Diabetic kidney disease(DKD) is the most common cause of chronic kidney disease(CKD) and end-stage renal disease(ESRD),and CKD is closely related to dyslipidemia and ectopic lipid deposition(ELD).Previous studies have shown that hyperlipidemia can lead to the occurrence and progression of CKD,as well as DKD.Lipid regulating drugs can improve the renal prognosis of patients with type 2 diabetes mellitus(T2DM).Hyperglycemia,hypertriglyceridemia and low high density lipoprotein-cholesterol may play important roles in the development of DKD.Therefore,the relationship between abnormal lipid metabolism and DKD was discussed,and the potential mechanism of DKD lipid induced renal damage was analyzed to provide some reference for clinical diagnosis and treatment.