胃癌患者不同组织内 MACC1和c-Met的表达及其临床意义

MACC1 and c-Met Expression and Clinical Value in Different Tissues of Patients with Gastric Cancer

【目的】探讨胃癌患者不同组织内结肠癌转移相关基因1(MACC1)和肝细胞生长因子受体(c-Met)的表达及其临床意义。【方法】回顾分析在本院行根治性手术治疗的133例胃癌患者的临床资料,术后取癌组织与癌旁组织分别检测MACC1、c-Met的表达。对比不同组织内MACC1、c-Met阳性检出率及MACC1mRNA、c-MetmRNA相对表达量,对比不同临床病理特征胃癌患者MACC1、c-Met阳性检出率差异。比较癌组织MACC1及c-Met阳性、阴性患者术后3年存活率的差异。【结果】癌组织MACC1、c-Met阳性检出率显著高于癌旁组织(P<0.05)。癌组织MACC1mRNA、c-MetmRNA相对表达量显著高于癌旁组织(P<0.05)。不同性别、年龄、肿瘤直径、肿瘤位置、组织类型患者癌组织MACC1、c-Met阳性检出率比较,差异无统计学意义(P>0.05);TNM分期Ⅲ或Ⅳ期、浸润深度T3或T4、Lauren's分型肠型、分化程度低或未分化、淋巴结转移患者癌组织MACC1、c-Met阳性检出率明显增高(P<0.05)。133例患者3年病死率为33.08%(44/133),Kaplan-Meier生存分析显示,癌组织MACC1和c-Met阳性检出率越高患者存活率越低(P<0.05)。【结论】胃癌患者癌组织内MACC1、c-Met高表达与疾病的进展、侵袭、转移和预后关系密切。

【Objective】To observe the expression and clinical application value of MACC1 and c-Met in different tissues of gastric cancer patients.【Methods】The clinical data of 133 patients with gastric cancer who underwent radical surgical treatment were retrospectively analyzed.The expression of MACC1 and hepatocyte growth factor receptor(c-Met)were detected in cancerous and adjacent tissues after surgery.The positive protein detection rates of MACC1 and c-Met,and the relative mRNA expression levels of MACC1 and c-Met in different tissues were compared.The positive detection rates of MACC1 and c-Met in gastric cancer patients with different clinicopathological features were compared as well.Finally,the difference in postoperative survival rate of patients with positive and negative MACC1 and c-Met were follow-up.【Results】The positive detection rates of MACC1 and c-Met in cancerous tissues were significantly higher than those in adjacent tissues(P<0.05).The relative expression levels of MACC1 mRNA and c-Met mRNA in cancer tissues were significantly higher than those in adjacent tissues(P<0.05).There were no significant differences in the positive detection rates of MACC1 and c-Met in cancer tissues of patients with different gender,age,tumor diameter,tumor location and tissue type(P>0.05).The positive rates of MACC1 and c-Met were significantly increased in patients with TNM stageⅢorⅣ,infiltration depth T3 or T4,Lauren's intestinal type,low differentiation or undifferentiation,lymph node metastasis(P<0.05).The 3-year mortality was 33.08%(44/133).Kaplan-meier survival analysis showed that the higher the positive rate of MACC1and c-Met in cancer tissue,the lower the survival rate of patients(P<0.05).【Conclusion】High expression of MACC1 and c-Met in cancer tissues of gastric cancer patients is closely related to the progression,invasion,metastasis prognosis of the disease.