肠道菌群紊乱与昼夜节律改变及2型糖尿病的关系研究进展

Research progress on the relationship between intestinal microbiota disorder and circadian rhythm change and type 2 diabetes mellitus

近期越来越多的研究着重于代谢性疾病患者生活方式的分析,提示昼夜节律的紊乱与2型糖尿病密切相关,而肠道菌群在其中起着不可或缺的作用。肠道菌群可通过短链脂肪酸、胆汁酸等代谢物、分泌激素、产生细胞因子作用于肠上皮细胞等多个方面影响宿主的昼夜节律,进一步影响机体的糖脂代谢,从而介导2型糖尿病的发生发展。文章主要就肠道菌群在昼夜节律及2型糖尿病发生发展中的作用进行综述。

Recently, more and more studies have focused on the analysis of the lifestyle of patients with metabolic diseases, suggesting that the disturbance of circadian rhythm is closely related to type 2 diabetes mellitus, and gut microbiota plays an indispensable role in it. Intestinal microbiota can affect the circadian rhythm of the host through short-chain fatty acids, bile acids and other metabolites, secretion of hormones, production of cytokines and action on intestinal epithelial cells, and further affect the glucose and lipid metabolism of the body, thereby mediating the occurrence and development of type 2 diabetes mellitus. This article mainly reviews the role of gut microbiota in circadian rhythm and the development of type 2 diabetes mellitus.