小胶质细胞在创伤后应激障碍中作用机制的研究进展

Research progress on the mechanism of microglia in post-traumatic stress disorder

创伤后应激障碍(PTSD)指机体在经历或目睹较为严重的身心打击后,延迟和持续出现再体验,逃避心理,警觉性升高、社会不适应等精神障碍症状。尽管在精神健康障碍的神经生物学方面,我们的研究已经取得了重大进展,但由于病理生理机制的繁杂和交互作用,仍然存在大量的问题需要进一步攻克。大量证据表明小胶质细胞活动与PTSD的发生发展联系密切,探索小胶质活动对PTSD影响的细胞和分子机制,有利于新的治疗靶点的探索。文章主要就小胶质细胞在PTSD发生发展中的重要作用进行综述。

Post-traumatic stress disorder refers to the delayed and persistent symptoms of the body after experiencing or witnessing a serious physical and psychological shock, including evasion, higher alertness, social maladjustment and other mental disorders. Our researches have made significant progress in the neurobiology of mental disorders. However, due to the complexity and interaction of pathophysiological mechanisms, there are a large number of problems that need to be overcome. A large amount of evidence shows that the activity of microglia is closely related to the cause and development of post-traumatic stress disorder. Exploring the cellular and molecular mechanisms of the influence of microglial activity on post-traumatic stress disorder is conducive to the exploration of new therapeutic targets. The article mainly reviews the significant role of microglia in the occurrence and development of PTSD.