FeNO及外周血嗜酸性粒细胞在慢性气道疾病中的综合价值

Comprehensive value of FeNO and peripheral blood eosinophils in chronic airway diseases

目的本研究旨在确定呼出气一氧化氮(FeNO)水平增加和血嗜酸性粒细胞(EOS)计数的组合是否对慢性气道疾病具有附加价值。方法我们纳入156名受试者,分为哮喘(n=30)、慢性阻塞性肺病(简称慢阻肺)(n=42)、慢性咳嗽(n=39)和健康者(n=45)。研究FeNO水平、EOS计数与慢性气道疾病发病风险的风险相关关系。结果FeNO水平和EOS计数增加与哮喘风险增加相关。FeNO水平增加与慢性咳嗽风险增加相关,但EOS计数增加与其无关。与FeNO<25ppb和EOS计数<0.3×10^(9)/L的个体相比,FeNO水平≥25ppb和EOS计数≥0.3×10^(9)/L,发生哮喘的风险均增加。FeNO水平≥25ppb,发生慢性咳嗽的风险增加。当两种生物标志物结合时,FeNO水平≥25ppb且EOS计数≥0.3×10^(9)/L,发生哮喘和慢性咳嗽的风险均增加。当分析哮喘和慢阻肺两组受试者时,与慢阻肺相比,FeNO水平≥25ppb且EOS计数≥0.3×10^(9)/L,发生哮喘风险增加。当分析慢阻肺和慢性咳嗽患者时,与慢阻肺相比,FeNO水平≥25ppb且EOS计数≥0.3×10^(9)/L,发生慢性咳嗽风险增加。结论FeNO和EOS的组合在慢性气道疾病方面可能具有附加价值,但仍需要进一步研究临床应用。

Objective To determine whether the combination of increased exhaled nitric oxide(FeNO)level and blood eosinophil(EOS)count has additional value for chronic airway diseases.Methods It included 156 subjects who were divided into the asthma group(n=30),the chronic obstructive pulmonary disease(COPD)group(n=42),the chronic cough group(n=39)and the healthy subject control group(n=45).The risk correlation between exhaled nitric oxide level,blood eosinophil count and the risk of chronic airway disease was studied.Results Increased FeNO level and EOS count were associated with an increased risk of asthma.Increased FeNO level was associated with the increased risk of chronic cough,but increased EOS count showed no association with it.Compared with FeNO<25ppb and EOS count<0.3×10^(9)/L among individuals,those with FeNO level≥25ppb and EOS count≥0.3×10^(9)/L had higher risk of asthma.When the two biomarkers were combined,they increased the risk of asthma and chronic cough.Compared with the COPD group,those patients with FeNO level≥25ppb and EOS count≥0.3×10^(9)/L increased the risk of asthma in the asthma group,and they also increased the risk of chronic cough in the chronic cough group.Conclusion The combination of FeNO and blood eosinophils may have additional value in characterizing chronic airway diseases,but further research and clinical application are still needed.