纤维粘连蛋白在后发性白内障纤维化进展中的作用研究现状

Current status of research on the role of fibronectin in the progression of posterior capsular opacification fibrosis

后发性白内障(PCO)是白内障手术后遗留的晶状体上皮细胞(LECs)发生上皮-间质转化(EMT),产生不透明的瘢痕组织,是白内障手术的主要并发症之一。白内障术后遗留的LECs产生的大量纤维粘连蛋白(FN)与多种细胞表面受体、基质成分和生长因子结合,调节细胞行为。本文旨在回顾有关PCO以纤维粘连蛋白为靶点治疗的文献,并为PCO的临床治疗提供参考。现将近年来纤维粘连蛋白在PCO中的研究现状予以综述。

Posterior cataract opacification(PCO) is the epithelial-mesenchymal transformation(EMT) of residual lens epithelial cells(LECs) after cataract surgery, resulting in opaque scar which is one of the main complications of cataract surgery. A large amount of fibronectin(FN) produced by LECs after cataract surgery binds to a variety of cell surface receptors, matrix components and growth factors to regulate cell behavior. The purpose of this article is to review the literatures on the treatment of PCO targeting fibronectin and provide references for clinical treatment of PCO. In this paper, the research status of fibronectin in PCO in recent years is reviewed.