基于角膜接触镜的眼部长效给药技术研究进展

Progress on contact lens for extended ophthalmic drug delivery

传统眼用制剂如滴眼液等存在药物利用率低、患者依从性差等问题。用于视力矫正的角膜接触镜(CL)具有良好的生物相容性和长期配戴舒适度,并能延长药物停留时间、提高生物利用度,成为很有前景的眼部给药载体。为了提高CL的药物负载量并延长药物释放时间,研究者开发了多种策略对传统CL进行改良,包括引入维生素E分子屏障,基于分子印迹技术制备CL,引入特定基团以增加药物与聚合物基质之间的相互作用,负载胶体纳米颗粒或载药聚合物薄膜等。本文综述了载药CL的各种制备方法及其优缺点,并简要评述了CL作为眼部药物递送载体存在的问题及未来发展方向。

Conventional eye treatment formulation such as eye drops has shortcomings including low drug utilization and poor patient compliance. The contact lens(CL), well-known as visual correction lens, is considered to be a more promising ophthalmic drug delivery vehicle owing to its good biocompatibility, long-term wearing comfort, prolonged drug residence time and improved bioavailability. In order to improve the drug loading efficiency and prolong the release time, researchers have developed a variety of strategies to modify traditional CL, including the introduction of vitamin E molecular barrier, application of molecular imprinting technology of CL, increasing interactions between the drug and polymer matrix by introducing special genes, and incorporation of nanocarriers or drug-loaded polymer films. In this paper, the preparation methods and pros and cons of drug-loaded CL are reviewed. At last, the existing problems and future developments of CL as ophthalmic drug delivery carrier are briefly discussed.