代谢组学及其在环境毒理学中的应用

Metabolomics and its Application in Environmental Toxicology

代谢组学作为系统生物学的一部分,因其具有分析速度快的特点,被广泛用于生物医学等方面的研究。目前代谢组学在环境毒理学方面的研究主要针对单一污染物,但也需要考虑到被污染地的复杂情况。通过介绍代谢组学及其发展历程,总结了目前主流代谢组学技术的各自特点,讨论了代谢组学在环境重金属、有机污染物和抗生素中的毒性评估以及环境胁迫耐受性中的评价等方面内容,综述了其在环境毒理学中的应用,并指出其应用不足,旨在为代谢组学应用于环境毒理学的研究提供参考。

As a part of system biology,metabolomics is widely used in biomedical research because of its fast analysis.At pres⁃ent,the studies of metabolomics in environmental toxicology mainly focus on single pollutants,and the complex situation of con⁃taminated areas should also be considered.The application of metabolomics in environmental toxicology was reviewed by intro⁃ducing metabolomics and its development process.We also summarized the respective characteristics of the current mainstream metabolomics technology,and discussed the research and application progress of metabolomics in the toxicity evaluation of envi⁃ronmental heavy metals,organic pollutants and antibiotics,and environmental stress tolerance evaluation.At last,we pointed point out that the application of metabolomics in environmental toxicology needs to be strengthened.The paper was expected to provide reference for the application reasearch of metabonomics in environmental toxicology.