摘要
本文研究了以喜树碱为底物,通过与腈类化合物在酸性条件下反应直接获得20位酯化喜树碱衍生物的方法,该方法避免了常用酯化反应中使用昂贵的催化剂,具有成本低,步骤短,操作方便等优点。
In this paper,the method of directly obtaining 20 position esterified camptothecin derivatives by reaction with nitrile compounds under acidic conditions with camptothecin as substrate was studied.This method avoided the use of expensive catalysts in common esterification reactions,and had the advantages of low cost,short steps and convenient operation.
作者
柯希
赵长阔
黄枫
王先恒
KE Xi;ZHAO Chang-kuo;HUANG Feng;WANG Xian-heng(Key Laboratory of Basic Pharmacology of Ministry of Education and Joint International Research Laboratory of Ethnomedicine of Ministry of Education,Zunyi Medical Universyty,Zunyi 563000,China;Pharmacy School,Zunyi Medical University,Zunyi 563000,China)
出处
《化学研究与应用》
CAS
CSCD
北大核心
2022年第9期2211-2215,共5页
Chemical Research and Application
基金
贵州省优秀青年科技人才项目(黔科合平台人才[2019]5657)资助
贵州省科技支撑项目(黔科合支撑2019[2829]资助)资助
院级招标课题项目([2013]F-680)资助
遵义市科技项目(遵市科合HZ字2019[26])资助。
关键词
喜树碱
三氟甲磺酸
腈
酯化
camptothecin
trifluoromethanesulfonic acid
nitrile
esterification
