度拉糖肽联合二甲双胍治疗对2型糖尿病的临床分析

Clinical Analysis of Dulaglutide Combined with Metformin in the Treatment of Type 2 Diabetes

目的分析度拉糖肽联合二甲双胍治疗对2型糖尿病的疗效及安全性分析。方法选取2018年1月—2020年12月期间在普洱市人民医院内分泌科住院治疗的2型糖尿病患者75例为研究对象,参照随机数表将患者分为两组,对照组36例,给予二甲双胍治疗,观察组39例,给予二甲双胍联合度拉糖肽治疗。两组患者治疗3个月后比较血糖、血脂等指标变化及治疗安全性分析。结果两组患者治疗后空腹血糖(FPG)及餐后2 h血糖(2 hPG)均降低,观察组糖化血红蛋白(HbAlc)低于治疗前,而观察组FPG、2 hPG相比于对照组明显更低,差异有统计学意义(P<0.05)。治疗后,两组患者的三酰甘油(TG)、胆固醇(CHO)值较治疗前降低。与对照组比较,观察组CHO、TG值降低程度更明显,差异有统计学意义(P<0.05)。两组患者在治疗期间均未出现严重不良反应。结论二甲双胍联合度拉糖肽可更好地控制血糖,降低体质量,伴血脂降低,临床疗效显著,且安全性高。

Objective To analyze the efficacy and safety of dulaglutide combined with metformin in the treatment of type 2 diabetes.Methods A total of 75 patients with type 2 diabetes who were hospitalized in the Endocrinology Department of Pu’er City People’s Hospital from January 2018 to December 2020 were selected as the research objects.The patients were divided into two groups with reference to the random number table,36 cases in the control group were given metformin treatment,and 39 cases in the observation group were given metformin combined with dulaglutide treatment.After 3 months of treatment,the changes of blood glucose,blood lipid and other indicators were compared between the two groups and the analysis of the safety of the treatment.Results The fasting blood glucose(FPG)and 2 h postprandial blood glucose(2 hPG)of the two groups were decreased after treatment,and the glycated hemoglobin(HbAlc)of the observation group was lower than that before treatment,however,the FPG and 2 hPG in the observation group were significantly lower than the control group,and the differences were statistically significant(P<0.05).After treatment,the triglyceride(TG)and cholesterol(CHO)values of the two groups of patients were lower than those before treatment,compared with the control group,the and TG values of the observation group decreased more significantly,and the difference was statistically significant(P<0.05).There were no serious adverse reactions in the two groups of patients during the treatment period.Conclusion Metformin combined with dulaglutide can better control blood glucose,reduce body weight,and reduce blood lipids,with significant clinical efficacy and high safety.