胰岛素静脉滴注在糖尿病合并鼻咽癌患者放疗期的应用效果

Application Effect of Insulin Intravenous Drip in Patients with Diabetes Mellitus Complicated with Nasopharyngeal Carcinoma during Radiotherapy

目的探究在对糖尿病合并鼻咽癌患者进行放射治疗期间将静脉滴注胰岛素开展应用对患者血糖指标与放射性皮炎的临床干预效果。方法选取2018年1月—2021年10月福建医科大学附属第一医院的100例糖尿病合并鼻咽癌患者为研究对象,随机分为对照组与研究组各50例,给予对照组患者常规口服盐酸二甲双胍片血糖控制,给予研究组患者应用静脉滴注胰岛素血糖控制,对其干预后的血糖指标、皮肤损伤程度、患者满意度进行比较。结果干预后,研究组患者的空腹血糖、餐后2 h血糖分别为(6.87±0.53)、(8.91±0.39)mmol/L均优于对照组,差异有统计学意义(P<0.05)。研究组患者的放射性皮炎发生率为32.00%,低于对照组差异有统计学意义(P<0.05)。此外,研究组患者的满意度为96.00%高于对照组的82.00%,差异有统计学意义(P<0.05)。结论在糖尿病合并鼻咽癌患者放射治疗中将静脉滴注胰岛素应用,其效果显著,可将患者的血糖进行有效控制,对皮肤损伤程度进行改善,减少患者的放射性皮炎发生率,促进患者恢复,提高患者满意度。

Objective To explore the clinical intervention effect of intravenous infusion of insulin on blood glucose indexes and radiodermatitis in patients with diabetes mellitus complicated with nasopharyngeal carcinoma during radiotherapy.Methods Relevant research was carried out in the First Affiliated Hospital of Fujian Medical University.The research time was from January 2018 to October 2021,and 100 patients were selected as the research objects,all of whom were diabetic patients with nasopharyngeal carcinoma.They were randomly divided into control group and study group with 50 cases in each group.The control group was given routine oral metformin hydrochloride tablets to control blood glucose,and the study group was given intravenous insulin to control blood glucose.The blood glucose indexes,the degree of skin damage and the patient satisfaction were compared after the intervention.Results After the intervention,the fasting blood glucose and 2 h postprandial blood glucose of the study group were(6.87±0.53)mmol/L and(8.91±0.39)mmol/L,which were better than those of the control group,the difference was statistically significant(P<0.05).The incidence of radiation dermatitis in the study group was 32.00%,which was lower than that in the control group,the difference was statistically significant(P<0.05).In addition,the satisfaction rate of patients in the study group was 96.00%higher than that in the control group 82.00%,and the difference was statistically significant(P<0.05).Conclusion Intravenous infusion of insulin is effective in radiotherapy for patients with diabetes and nasopharyngeal carcinoma.It can effectively control the blood glucose of patients,improve the degree of skin damage,reduce the incidence of radiation dermatitis in patients,promote patient recovery,and improve patient satisfaction.