胰岛素结合格列本脲对妊娠期糖尿病患者妊娠结局及血清炎症指标的影响

Effects of Insulin Combined with Glyburide on Pregnancy Outcomes and Serum Inflammatory Markers in Patients with Gestational Diabetes Mellitus

目的分析胰岛素结合格列本脲对妊娠期糖尿病患者妊娠结局及血清炎症指标的影响。方法选择2019年1月—2021年12月黑龙江省齐齐哈尔市一厂医院收治的92例妊娠期糖尿病患者为研究对象,采用随机数表法分为对照组和观察组,各46例。对照组采取单纯胰岛素注射治疗,观察组采取胰岛素注射联合格列本脲治疗。在治疗3个月后比较两组患者的妊娠结局及血清炎症指标情况[摄食抑制因子(Nesfatin-1)、鸢尾素(Irisin)]、血糖值。结果入院前,两组患者血清炎症指标比较,差异无统计学意义(P>0.05);治疗3个月后,两组患者血清指标均改善,且观察组患者Nesfatin-1高于对照组,Irisin低于对照组,差异有统计学意义(P<0.05)。观察组患者剖宫产、流产、早产发生率低于对照组,差异有统计学意义(P<0.05)。入院时,两组患者血糖指标比较,差异无统计学意义(P>0.05);治疗3个月后,两组患者血糖指标均改善,且观察组血糖指标低于对照组,差异有统计学意义(P<0.05)。结论对妊娠期糖尿病患者采用胰岛素结合格列本脲治疗后,能够减少患者不良妊娠结局,改善患者体内血清炎症指标,具有一定的临床应用价值。

Objective To analyze the effect of insulin combined with glyburide on pregnancy outcome and serum inflammatory indexes in patients with gestational diabetes mellitus.Methods A total of 92 patients with gestational diabetes mellitus who were admitted to the First Factory Hospital of Qiqihar City,Heilongjiang Province from January2019 to December 2021 were selected as the research objects,and divided into the control group and the observation group by random number table method,with 46 cases in each group.The control group was given insulin injection alone,while the observation group was given insulin injection combined with glyburide.After 3 months of treatment,the pregnancy outcomes and serum inflammatory indexes[feeding inhibitor(Nesfatin-1),irisin(Irisin)]and blood glucose levels were compared between the two groups.Results Before admission,there was no statistically significant difference in serum inflammatory indexes between the two groups(P>0.05);after 3 months of treatment,the serum indexes of the two groups were improved,and the nesfatin-1 of the observation group was higher than that of the control group,and the irisin was lower than that of the control group,and the difference was statistically significant(P<0.05).The incidence of cesarean section,abortion and preterm birth in the observation group was lower than that in the control group,and the difference was statistically significant(P<0.05).At admission,there was no statistically significant difference in blood glucose between the two groups(P>0.05);after 3 months of treatment,the blood glucose indexes of the two groups were improved,and the blood glucose indexes of the observation group were lower than that of the control group,and the difference was statistically significant(P<0.05).Conclusion Insulin combined with glyburide therapy for gestational diabetes patients can reduce adverse pregnancy outcomes and improve serum inflammatory indexes in patients,which has certain clinical application value.