比较胰岛素泵与多次皮下注射胰岛素在儿童1型糖尿病中的疗效与安全性

Comparison of Efficacy and Safety of Insulin Pump and Multiple Subcutaneous Insulin Injections in Children with Type 1 Diabetes

目的探讨胰岛素泵与多次皮下注射胰岛素在儿童1型糖尿病中的疗效与安全性。方法选取2019年1月—2022年1月贵阳市妇幼保健院收治的60例儿童1型糖尿病患儿作为研究对象,用随机数表法将其分对照组和观察组,各30例。对照组接受多次皮下注射胰岛素,观察组接受胰岛素泵持续皮下注射胰岛素。比较两组患儿血糖指标、血糖达标时间、胰岛素用量、低血糖发生状况等。结果治疗后,观察组餐后2 h血糖、空腹血糖低于对照组,差异有统计学意义(P<0.05);观察组血糖达标时间短于对照组,胰岛素用量、低血糖发生频次低于对照组,差异有统计学意义(P<0.05)。结论儿童1型糖尿病患儿接受胰岛素泵持续皮下注射胰岛素,相比于多次皮下注射胰岛素,能更好地控制血糖,并可降低胰岛素用量。

Objective To investigate the efficacy and safety of insulin pump and multiple subcutaneous insulin injections in children with type 1 diabetes.Methods A total of 60 children with type 1 diabetes who were admitted to Guiyang Maternal and Child Health Hospital from January 2019 to January 2022 were selected as the research objects,and they were divided into the control group and the observation group by random number table method,with 30 cases in each group.The control group received multiple subcutaneous injections of insulin,and the observation group received continuous subcutaneous insulin injections with an insulin pump.The blood glucose indicators,time to reaching the blood glucose standard,insulin dosage,and occurrence of hypoglycemia were compared between the two groups.Results After treatment,the 2 h postprandial blood glucose and fasting blood glucose in the observation group were lower than those in the control group,and the difference was statistically significant(P<0.05).The time to reach the blood glucose standard in the observation group was shorter than that in the control group,and the insulin dosage and frequency of hypoglycemia were lower than those in the control group,and the differences were statistically significant(P<0.05).Conclusion Children with type 1 diabetes who receive continuous subcutaneous insulin injection with insulin pump can better control blood glucose than multiple subcutaneous insulin injections and can reduce insulin dosage.