微炎症状态在慢性肾脏病血管钙化中作用研究进展

Research advances on the role of microinflammatory state in vascular calcification in chronic kidney disease

目前,中国的慢性肾脏病(chronic kidney disease,CKD)发病率逐年增加。血管钙化(vascular calcification,VC)作为CKD患者心血管不良状态的主要原因之一,其并未具有完全明确的形成机制,而微炎症状态与VC的形成密切相关,其主要通过单核吞噬细胞系统激活、肿瘤坏死因子α、白细胞介素、C反应蛋白、炎症指标比值等释放参与VC的发生、发展。

The annual incidence of chronic kidney disease(CKD)is rising rapidly in China.It causes a high economic burden on health system.Vascular calcification(VC)is one of the major causes of cardiovascular adverse events in CKD patients.The formation mechanism of VC has not been com⁃pletely elucidated.Microinflammatory state is closely correlated with the formation of VC.The activa⁃tion of monocyte phagocyte system,the releases of tumor necrosis factorα,interleukin,C-reactive pro⁃tein and ratio of inflammatory parameters may participate in the occurrence and development of VC.