Treg调控ILC2参与炎症性疾病的研究进展

Role of Treg in regulation of ILC2 in inflammatory diseases

二型固有淋巴细胞(ILC2)是一类表面缺乏特异性抗原识别受体的固有免疫细胞,可被IL-33、IL-25及胸腺基质淋巴细胞生成素(TSLP)等细胞因子活化而释放二型细胞因子,如IL-5和IL-13,进而发挥抗寄生虫感染作用。研究发现,ILC2的过度激活与哮喘、皮炎等炎症性疾病的发生密切相关,抑制ILC2的活化已成为治疗ILC2诱导疾病的重要策略。调节性T细胞(Treg)是一类重要的具有负向免疫调节功能的CD4~+T细胞亚群,在改善炎症性疾病的进程中发挥重要作用。近年研究发现,Treg可通过多种方式调控ILC2的活化从而缓解炎症性疾病进程。本综述总结了Treg调控ILC2活化的作用机制及其在不同炎症性疾病中扮演的角色,以期为深入研究炎症性疾病中Treg与ILC2的相互作用和炎症性疾病的治疗提供参考。

Group 2 innate lymphoid cells(ILC2s)are a group of innate immune cells that lack specific antigen recognition receptors,which can be activated by IL-33,IL-25 and thymic stromal lymphopoietin(TSLP)and produce type 2 cytokines,such as IL-5 and IL-13,which exert an anti-parasitic infection effect. Studies have found that the excessive activation of ILC2 is closely associated with development of many inflammatory diseases,such as asthma and dermatitis. Suppressing activation of ILC2 has become an important strategy for treatment of ILC2-induced diseases. Regulatory T cells(Tregs)are important CD4T cell subset that has a negative immunomodulatory and plays an important role in attenuating inflammatory diseases. In recent years,studies have found that Treg can alleviate some inflammatory diseases via regulating activation of ILC2 in a variety of ways. This review summarizes the mechanism by which Treg regulates ILC2 and their role in different inflammatory diseases,aiming to provide a reference for further study of interaction between Treg and ILC2 and its therapeutic value in inflammatory diseases.