一例疑似非阿尔茨海默病的病理生理改变所致痴呆的临床分析

Clinical analysis on a case of dementia caused by suspected non-Alzheimer's disease pathophysiological

目的:报道一例疑似非阿尔茨海默病病理生理改变(SNAP)的病例,以提高对该疾病的认识。方法:分析SNAP的临床特征、脑脊液病理生物标志物和影像学改变的特点。结果:患者为中年男性,临床表现为认知损害,神经心理量表评估提示中度认知功能损害,脑脊液中Aβ42水平和Aβ42/Aβ40比值均在正常范围,但是p-Tau181的水平显著增高,MRI影像示双侧海马明显萎缩。结论:临床诊断支持SNAP。

Objective:Reported a case of suspected non-Alzheimer's disease pathophysiology(SNAP)to improve our understanding of the disease.Methods:Analyzed the clinical features,cerebrospinal fluid pathological biomarkers and imaging changes of SNAP,and reviewed relevant literature.Results:The patient was a middle-aged man with cognitive impairment,his neuropsychological scale assessment suggested moderate cognitive impairment,the level of Aβ42 and Aβ42/Aβ40 ratios in cerebrospinal fluid were all within the normal range,but the level of p-Tau181 was significantly increased,and MRI images showed significant bilateral hippocampus atrophy.Conclusion:The clinical diagnosis supported SNAP.