血液病患者红细胞输注无效的影响因素分析

Influencing factors analysis of erythrocyte transfusion refractoriness with hematological diseases

目的探讨红细胞输注无效的影响因素,分析红细胞输注无效的原因。方法选取2020年12月至2021年12月期间嘉兴市三甲医院血液科红细胞输注患者861例,采用单因素分析和多因素logistic回归分析红细胞输注无效的影响因素。结果861例患者红细胞输注无效率为30.31%(261/861),单因素分析显示性别、输血史、Rh输注类型,疾病类型为红细胞输注无效的影响因素(χ2分别=58.75、39.61、42.61、59.69,P均<0.05)。多因素logistic回归分析结果显示:女性、白血病/淋巴瘤、骨髓增生异常综合征(MDS)/多发性骨髓瘤(MM)、血小板减少症、有输血史、O型、Rh(E/C)盲配会增加红细胞输注无效发生的风险(OR分别=2.75、25.24、29.82、3.96、2.08、2.23、7.35,P均<0.05)。结论血液病患者红细胞输注无效与性别、疾病类型、输血史、病人血型、Rh输注类型有关联性。

Objective To explore the influencing factors of erythrocyte transfusion refractoriness,and analyze the reasons for erythrocyte transfusion refractoriness.Methods A total of 861 cases of erythrocyte transfusion in the he-matology departmen of the municipal third-class hospitals in Jiaxing from December 2020 to December 2021 were se-lected.The univariate analysis and multivariate logistic regression were used to analyze the influencing factors of eryth-rocyte transfusion effect.Results The ineffective rate of rerythrocyte transfusion in 861 cases was 30.31%(261/861).Gender,blood transfusion history,type of Rh transfusion,and types of disease were the influencing factors of erythro-cyte transfusion refractoriness(χ2=58.75,39.61,42.61,59.69,P<0.05).The results of multivariate logistic regression analysis showed that female,leukemia/lymphoma,myelodysplastic syndrome(MDS)/multiple myeloma(MM),thrombo-cytopenia,blood transfusion history,O type,Rh(E/C)blindness matching increases the risk of erythrocyte transfusion ineffectiveness(OR=2.75,25.24,29.82,3.96,2.08,2.23,7.35,P<0.05).Conclusion The effect of erythrocyte tran-sfusion in patients with hematological diseases is related to gender,disease type,blood transfusion history,patient blood type,and Rh transfusion type.