摘要
Real-time monitoring and accurate treatment are of great significance for reducing the side effects during the cancer therapy.In this work,we rationally prepared a smart nanoprobe based on core-shell terbium metal-organic gramework(MOF)with highly effective photothermal conversion capacity and drug release efficiency under near-infrared light irradiation for real-time fluorescence imaging-guided multimodal therapy.The nanoprobe can achieve prominent photothermal therapy and controllable drug release,act as a fluorescence thermometer,and also real-time feedback of temperature is expected to be achieved.At the same time,the two-photon ligand design significantly improves the tissue penetration ability of the nanoprobe.Our work is expected to provide a reference for precise treatment and real-time monitoring of tumors and at the same time provide new ideas for the formulation of individualized treatment plans.
基金
Project supported by the National Natural Science Foundation of China(21871121)
Science and Technological Plan of Gansu Province(20YF3GA012)
the 111 Project(B20027)。