乳腺癌新辅助化疗靶向淋巴结定位技术

Targeted lymph node localization in neoadjuvant chemotherapy for breast cancer

新辅助化疗可使腋窝淋巴结转移的乳腺癌患者达到病理完全缓解,接受新辅助化疗后腋窝淋巴结由阳转阴的患者行前哨淋巴结活检术是目前乳腺癌的研究热点。面对新辅助化疗后前哨淋巴结活检手术假阴性率高的问题,进一步提出靶向淋巴结切除手术,即在开始新辅助化疗前用标记夹、碳悬浮液、放射性和磁性粒子、雷达反射器和射频识别定位设备标记活检证实的阳性淋巴结然后在治疗后进行切除。本文旨在对上述淋巴结定位技术进行综述。

Neoadjuvant chemotherapy(NACT) can achieve pathological complete remission in breast cancer patients with positive axillary lymph node, and sentinel lymph node biopsy(SLNB) in patients is a research hotspot of breast cancer treatment at present. However, facing the problem of high false-negative rate of SLNB after NACT, targeted lymph nodes dissection was proposed, namely, the positive lymph nodes was confirmed and localized with tissue marker clips, carbon suspension, radioactive and magnetic seeds, radar reflectors and radiofrequency identification before NACT and then removed after treatment. This paper aims to review the above-mentioned lymph node localization techniques.