摘要
The events occurring before and soon after birth appear to impact an individual’s health throughout adulthood significantly.The pioneering work of David J.P.Barker studied the nutritional status of 2414 pregnant women and their offspring during the Dutch famine between 1944 and 1945,and convincingly connected undernutrition during pregnancy to the predisposition of offspring to many adult-onset diseases,including cardiovascular disease.
作者
Guolian Ding
Bin Chen
John R.McCarrey
Hefeng Huang
丁国莲;陈宾;John R.McCarrey;黄荷凤(Obstetrics and Gynecology Hospital,Institute of Reproduction and Development,Fudan University,Shanghai 200011,China;Research Units of Embryo Original Diseases,Chinese Academy of Medical Sciences,Shanghai 200030,China;Key Laboratory of Reproductive Genetics(Ministry of Education),Department of Reproductive Endocrinology,Women’s Hospital,Zhejiang University School of Medicine,Hangzhou 310006,China;Assisted Reproduction Unit,Department of Obstetrics and Gynecology,Sir Run Run Shaw Hospital,School of Medicine,Zhejiang University,Key Laboratory of Reproductive Dysfunction Management of Zhejiang Province,Hangzhou 310016,China;Department of Neuroscience,Developmental and Regenerative Biology,University of Texas at San Antonio,San Antonio 78249,USA;Shanghai Key Laboratory of Embryo Original Diseases,Shanghai 200030,China)
基金
supported by the National Natural Science Foundation of China(82088102)
Chinese Academy of Medical Sciences Innovation Fund for Medical Sciences(2019-I2M-5-064)
Collaborative Innovation Program of Shanghai Municipal Health Commission(2020CXJQ01)
Clinical Research Plan of Shanghai Hospital Development Center(SHDC2020CR1008A)
Shanghai Frontiers Science Research Base of Reproduction and Development
Zhejiang Provincial Natural Science Foundation of China(LQ21H040005)。
