深海热液真菌Fusarium sp.SCSIO 06196中抗病毒聚酮类化学成分研究

Antiviral chromones from the deep-sea hydrothermal-vent-derived Fusarium sp.SCSIO 06196

从西太平洋深海热液沉积物来源的镰刀菌SCSIO 06196中分离鉴定了6个色原酮类化合物(1~6),通过核磁共振光谱、质谱及旋光等多种分析测试方法确定了色原酮类化合物的结构。抗病毒活性筛选发现,化合物1~3展示出显著的抗肠道病毒EV-71活性,IC_(50)分别达到26.7μmol·L^(-1)、19.8μmol·L^(-1)和22.0μmol·L^(-1)(阳性对照药物利巴韦林为177μmol·L^(-1))。此外,化合物1还显示出弱的抗流感病毒H3N2活性,IC_(50)为8.6μmol·L^(-1)(阳性对照药物达菲为18.5nmol·L^(-1))。

Six chromone derivatives(1~6)were identified from the fungus Fusarium sp.SCSIO 06196 isolated from deep-sea hydrothermal vent environments in the Western Pacific.Their structures were elucidated mainly by extensive Nuclear Magnetic Resonance(NMR)spectroscopic,mass spectrometric(MS)and rotational analysis.Antiviral activities of the compounds 1~6 were tested.Among these compounds,compounds 1~3 exhibited significant in vitro anti-enterovirus 71(EV-71)activities with IC_(50) values of 26.7,19.8,and 22.0μmol·L^(-1),respectively(IC_(50)=177μmol·L^(-1),Ribavirin).In addition,compound 1 showed weak antiviral activity against the H3N2 influenza virus with IC_(50) value of 8.6μmol·L^(-1)(IC_(50)=18.5 nmol·L^(-1),Tamiflu).