益生菌缓解或治疗炎症性肠病的作用及机制研究进展

Effect and Mechanism of Probiotics in Alleviating or Treating Inflammatory Bowel Disease

炎症性肠病(inflammatory bowel disease,IBD)是一种慢性且反复发作的肠道炎症性疾病,并且在中国的发病率逐渐升高。近年来,随着对IBD的深入研究,益生菌成为IBD治疗的新兴药物,并且某些益生菌能够通过参与肠道屏障的保护,调节免疫和炎性因子的表达来缓解或治疗IBD。同时,因益生菌具有抗炎、良好的耐受性和极少的不良反应等特性,也使其在IBD治疗的临床应用中越来越常见。本文主要从缓解或治疗IBD的益生菌分类、作用机制及临床研究等方面介绍了益生菌在IBD治疗中的研究进展。

Inflammatory bowel disease(IBD),gradually increasing in China,is a chronic and recurrent intestinal inflammatory disease.Recently,probiotics have been applied for the treatment of IBD,and some probiotic strains can alleviate or treat IBD by protection of the intestinal barrier and regulating expression of immune and inflammatory factors.Meanwhile,probiotics have the characteristics of good tolerability and few adverse reactions,resulting in their commonness in the clinical application of IBD treatment.This article mainly introduces the research progress of probiotics in the treatment of IBD,including the classification,mechanism of action and clinical research.