奥扎格雷钠联合阿司匹林治疗急性脑梗死患者疗效分析

Effect of ozagrel sodium combined with aspirin on coagulation function,platelet activity and nerve function in patients with acute cerebral infarction

目的:研究阿司匹林联合奥扎格雷钠治疗急性脑梗死(ACI)患者对其血小板活性、凝血功能及神经功能的影响。方法:选取本院64例急性脑梗死患者随机分组,对照组32例给予阿司匹林口服治疗,观察组32例接受奥扎格雷钠联合阿司匹林治疗,两周后,对比两组患者的临床疗效、神经功能水平、凝血功能和血小板活性。结果:观察组临床疗效率93.75%(29/32)高于对照组71.88%(23/32)(χ2=5.3791,P<0.05);两组患者凝血功能、血小板活性和神经功能均有不同程度改善,且观察组改善幅度明显高于对照组(P<0.05)。结论:阿司匹林联合奥扎格雷钠治疗急性脑梗死有显著疗效,能够通过抑制血小板聚集、恢复血栓素与前列腺素在机体内的平衡和保护神经细胞的机制,改善凝血功能、血小板活性以及神经功能。

Objective:To investigate the effect of aspirin combined with ozaggrel sodium on platelet activity,coagulation function and neurological function in patients with acute cerebral infarction(ACI).Methods:A total of 64 patients with acute cerebral infarction in our hospital were randomly divided into control group(n=32)and observation group(n=32).The control group received oral aspirin treatment,while the observation group received ozagrel sodium combined with aspirin treatment.After two weeks,the clinical efficacy,neurological function,coagulation function and platelet activity of the two groups were compared.Results:The clinical efficacy rate of the observation group was 93.75%(29/32)higher than that of the control group 71.88%(23/32)(χ2=5.3791,P<0.05).The coagulation function,platelet activity and neurological function of the two groups were improved in different degrees,and the improvement amplitude of the observation group was significantly higher than that of the control group(P<0.05).Conclusion:Ozaggrel sodium combined with aspirin has a significant effect in the treatment of acute cerebral infarction,which can improve coagulation function,platelet activity and nerve function by inhibiting platelet aggregation,restoring the balance between thromboxane and prostaglandin in the body and protecting the mechanism of nerve cells.