静息态脑功能磁共振成像在急性轻型脑外伤中的应用

Application of resting-state functional magnetic resonance imaging in acute mild traumatic brain injury

目的 分析静息态脑功能磁共振成像在急性轻型脑外伤临床中的应用效果。方法 选取北京博爱医院2019年5月至2021年5月收治的急性轻型脑外伤患者47例为观察组,同期行常规体检的健康人50例为对照组,采用静息态脑功能磁共振成像采集低频震荡幅度(ALFF),采用简易精神状态检查(MMSE)、蒙特利尔认知评定(MoCA)、Rivermead行为记忆功能测试(RBMT)进行评定。结果 与对照组相比,观察组MMSE、MocA、RBMT评分均显著降低(t>18.138,P<0.001);观察组ALFF降低的脑区包括小脑后叶、小脑扁桃体、下半月小叶、右侧颞上回、右侧颞中回、右侧顶叶和右侧中央后回等,ALFF升高的脑区包括边缘叶、扣带回、楔前叶、左侧小脑、右侧颞上回、右侧颞中回、右侧额上回、右侧额中回和右侧额下回等。结论 急性轻型脑外伤患者存在多个脑区异常改变,可能与认知障碍有关。

Objective To apply resting-state functional magnetic resonance imaging in acute mild traumatic brain injury.Methods From May,2019 to May,2021,47 cases with acute mild traumatic brain injury in Beijing Bo’ai Hospital were selected as observation group,and 50 healthy people who visited for routine physical examination during the same period were as control group.They were scanned with resting-state functional magnetic resonance imaging to measure amplitude of low-frequency fluctuation(ALFF),and they were assessed with Mini-Mental State Examination(MMSE),Montreal Cognitive Assessment(MoCA) and Rivermead Behavioural Memory Test(RBMT).Results Compared with the control group,the scores of MMSE,MoCA and RBMT decreased in the observation group(t>18.138,P<0.001);while ALFF decreased in the brain areas of posterior cerebellar lobe,cerebellar tonsils,lower half moon lobules,right superior temporal gyrus,right middle temporal gyrus,right parietal lobe and right central posterior gyrus,etc;and ALFF increased in the brain areas of marginal lobe,cingulate gyrus,precuneus,left cerebellar,right superior temporal gyrus,right middle temporal gyrus,right superior frontal gyrus,right middle frontal gyrus,right inferior frontal gyrus,etc.Conclusion There are disorders in multiple brain areas for patients after acute mild traumatic brain injury,which may associate to the cognitive impairment.