膜联蛋白A3在心血管系统中的作用

The roles of annexin A3 in cardiovascular system

膜联蛋白(ANX)是一类进化过程中高度保守的细胞内蛋白质,其名字最初来源于希腊语“annexin”,意为“结合在一起”。ANX通常以钙离子浓度依赖的方式与细胞膜磷脂结合,发挥胞吞、胞吐、转运、信号传递等功能。膜联蛋白A3(ANXA3)是ANX家族中重要的成员之一,大量研究发现其与肿瘤的演进有密不可分的关系。近些年,随着生物信息学技术的不断发展,越来越多的研究表明,ANXA3在心血管系统中也发挥着不可小觑的作用。深入揭示ANXA3在心血管系统中的作用,未来可望能够为心血管损伤相关疾病的防治提供新的思路与策略。

Annexin(ANX) is a highly conserved intracellular protein in the process of evolution. Its name originally comes from the Greek word “annexin”, meaning “to bind together”. ANX usually binds to the phospholipid of the cell membrane in a calcium-dependent manner and performs the functions of endocytosis, exocytosis, transport and signaling. Annexin A3(ANXA3) is an important member of the ANX family, a large number of studies have found that there is an inseparable relationship between ANXA3 and the evolution of tumors. However, in recent years, with the deepening of the scientific research and development of bioinformatics technology, more and more studies have shown that ANXA3 may also play a huge role in the cardiovascular system, meanwhile, the underlying mechanism is still largely unknown. Therefore, the in-depth study of the specific role of ANXA3 in the physiology and pathophysiology of the cardiovascular system may provide new ideas and strategies for the prevention and treatment of cardiovascular diseases in the future.