细胞质胸苷激酶1、鳞状细胞癌抗原在食管鳞状细胞癌中的表达及与临床特征、预后的关系

Expressions of cytoplasmic thymidine kinase 1 and squamous cell carcinoma antigen in esophageal squamous cell carcinoma and their relationship with clinical features and prognosis

目的探讨细胞质胸苷激酶1(TK1)、鳞状细胞癌抗原(SCCA)在食管鳞状细胞癌中的表达及与其临床特征、预后的关系。方法选取2018年1月至2020年1月于安徽省宣城市人民医院就诊的食管鳞状细胞癌患者102例(研究组),同期健康体检者97例(对照组),比较两组TK1、SCCA表达水平;对比不同临床病理特征食管鳞状细胞癌患者TK1、SCCA表达水平;分析影响食管鳞状细胞癌患者预后的危险因素。结果研究组TK1、SCCA水平高于对照组(P<0.05)。不同年龄、性别食管鳞状细胞癌患者TK1、SCCA表达水平比较,差异无统计学意义(P>0.05);临床分期Ⅰ~Ⅱ期、肿瘤直径>5 cm、有淋巴结转移者TK1、SCCA表达水平高于临床分期Ⅲ~Ⅳ期、肿瘤直径≤5 cm、无淋巴结转移者(P<0.05)。102例患者随访2年,死亡24例(23.53%),存活78例(76.47%)。临床分期Ⅲ~Ⅳ期、有淋巴结转移、TK1>2.0 pmol/L、SCCA>1.5 ng/ml是影响食管鳞状细胞癌患者预后的独立危险因素(P<0.05)。结论TK1、SCCA在食管鳞状细胞癌中表达均明显上升,临床可通过检测TK1、SCCA的表达水平评估患者的预后情况。

Objective To investigate the expressions of cytoplasmic thymidine kinase 1(TK1)and squamous cell carcinoma antigen(SCCA)in esophageal squamous cell carcinoma(ESCC)and their relationship with clinical features and prognosis.Methods One hundred and two patients with ESCC who were treated in Xuancheng People′s Hospital from January 2019 to November 2021 were selected as a study group,and 97 people undergoing healthy examination during the same period were selected as a control group.The expression levels of TK1 and SCCA were compared between the two groups.The expressions of TK1 and SCCA in different clinicopathological features of ESCC were also compared.The risk factors affecting the prognosis of the patients were analyzed.Results The levels of TK1 and SCCA in the study group were higher than those in the control group(P<0.05).There was no significant difference in the expression levels of TK1 and SCCA among the patients at different ages and genders(P>0.05).The expression levels of TK1 and SCCA in patients with clinical stageⅠ~Ⅱ,tumor diameter>5 cm,and lymph node metastasis were higher than those in clinical stageⅢ~Ⅳtumor diameter≤5 cm,and no lymph node metastasis(P<0.05).All patients were followed up for 2 years.After that,24 cases(23.53%)died and 78 cases(76.47%)survived.Clinical stage III-IV,lymph node metastasis,TK1>2.0 pmol/L,SCCA>1.5 ng/ml were independent risk factors affecting the prognosis of patients with ESCC(P<0.05).Conclusion The expression levels of TK1 and SCCA are significantly increased in ESCC.The prognosis of patients can be evaluated by detecting the expression levels of TK1 and SCCA.