Chemerin在口腔鳞状细胞癌患者血清及唾液中的表达及意义

Expression and significance of Chemerin in serum and saliva of patients with oral squamous cell carcinoma

目的探讨趋化蛋白Chemerin在口腔鳞状细胞癌(OSCC)患者血清及唾液中的表达及意义。方法收集80例OSCC患者(OSCC组)、50例癌前病变患者(癌前病变组)及50例健康体检者(对照组)的外周血和唾液,采用酶联免疫吸附试验检测血清及唾液中Chemerin水平并分析其与OSCC患者临床病理特征的相关性,然后绘制受试者工作特征曲线(ROC曲线)评价血清和唾液Chemerin水平对OSCC的诊断价值。结果OSCC组患者血清和唾液Chemerin水平均明显高于癌前病变组和对照组,且癌前病变组明显高于对照组(P<0.05);Chemerin水平与OSCC患者肿瘤最大径、TNM分期及淋巴结转移有关(P<0.05)。ROC曲线分析显示,血清和唾液Chemerin诊断OSCC的曲线下面积(AUC)分别为0.895和0.845;血清和唾液Chemerin鉴别诊断OSCC的AUC分别为0.736和0.729。结论Chemerin在OSCC患者血清和唾液中高表达,与患者病理特征相关,且诊断性能较好,可作为诊断OSCC的辅助指标。

Objective To investigate the expression and significance of Chemerin in serum and saliva of patients with oral squamous cell carcinoma(OSCC).Methods Peripheral blood and saliva were collected from 80 patients with OSCC(OSCC group),50 patients with precancerous lesions(precancerous lesion group)and 50 healthy subjects(control group).Chemerin levels in serum and saliva were detected by ELISA,and the correlation between Chemerin levels and clinicopathological features of OSCC patients was analyzed.Receiver operating characteristic(ROC)curves were drawn to evaluate the diagnostic value of serum and saliva Chemerin levels for OSCC.Results Serum and saliva Chemerin levels in OSCC group were significantly higher than those in precancerous lesion group and control group,and precancerous lesion group was significantly higher than control group(P<0.05).Chemerin level was associated with tumor size,TNM stage and lymph node metastasis in OSCC patients(P<0.05).ROC curve analysis showed that the area under curve(AUC)of serum and saliva Chemerin for OSCC diagnosis was 0.895 and 0.845,respectively.The AUC of serum and saliva Chemerin for differential diagnosis of OSCC was 0.736 and 0.729,respectively.Conclusion Chemerin is highly expressed in serum and saliva of OSCC patients,which is correlated with the pathological characteristics of patients and has good diagnostic performance.It can be used as an auxiliary indicator for the diagnosis of OSCC.