miR-152、CHIT1、SAA在2型糖尿病微血管并发症患者中的表达及临床意义

Expression and clinical significance of miR-152,CHIT1 and SAA in type 2 diabetic patients with microvascular complications

目的探讨微小核糖核酸-152(miR-152)、几丁质酶1(CHIT1)、血清淀粉样蛋白A(SAA)在2型糖尿病微血管并发症患者中的表达,分析其临床意义。方法回顾性收集2020年1月至2021年6月该院收治的168例2型糖尿病患者的临床资料,按照是否存在微血管并发症分为两组,其中单纯糖尿病组共88例,糖尿病微血管并发症组共80例。比较miR-152、CHIT1、SAA在两组间的表达差异,分析发生糖尿病微血管并发症的影响因素,探讨其预测价值。结果糖尿病微血管并发症组患者的病程、体质量指数(BMI)、合并高血压情况与单纯糖尿病组患者比较差异有统计学意义(P<0.05);糖尿病微血管并发症组患者的miR-152、CHIT1、SAA水平明显高于单纯糖尿病组患者,差异有统计学意义(P<0.05);miR-152、CHIT1、SAA升高是糖尿病微血管病变发生的独立危险因素(P<0.05);miR-152、CHIT1、SAA联合预测糖尿病微血管病变的曲线下面积(AUC)为0.856,灵敏度和特异度可达85.1%、70.2%。结论miR-152、CHIT1、SAA在2型糖尿病微血管并发症患者中明显升高,是影响糖尿病微血管并发症患者的独立危险因素,联合检测有助于预后评估,值得临床推广应用。

Objective To investigate the expression of microRNA-152(miR-152),chitinase 1(CHIT1)and serum amyloid A(SAA)in type 2 diabetic patients with microvascular complications,and to analyze their clinical significance.Methods The clinical data of 168 patients with type 2 diabetes admitted to our hospital from January 2020 to June 2021 were retrospectively collected.According to whether microvascular complications existed,they were divided into two groups:one group was the simple diabetes group(88 cases)and the other group was the diabetic microvascular complications group(80 cases).The expression differences of miR-152,CHIT1 and SAA between the two groups were compared,and the influencing factors and predictive value were analyzed.Results There were statistically significant differences in the course of disease,body mass index(BMI)and the rate of hypertension between diabetic microvascular complications group and simple diabetes group(P<0.05).The levels of miR-152,CHIT1 and SAA in patients in diabetic microvascular complications group were significantly higher than that of simple diabetes group(P<0.05).Increased levels of miR-152,CHIT1 and SAA were independent risk factors for diabetic microvascular complications(P<0.05).The area under the curve(AUC)of miR-152,CHIT1 and SAA combined prediction of diabetic microvascular complications was 0.856,with sensitivity and specificity were 85.1%and 70.2%respectively.Conclusion miR-152,CHIT1 and SAA are significantly increased in type 2 diabetic patients with microvascular complications,which are independent risk factors for diabetic microvascular complications.Combined detection is helpful for prognosis assessment and worthy of clinical application.