摘要
目的 探讨骨坏死康复丸治疗股骨头坏死肝肾亏虚证的临床疗效。方法 将纳入的80例股骨头坏死肝肾亏虚证患者随机分为试验组和对照组各40例,试验组口服骨坏死康复丸,对照组口服仙灵骨葆胶囊,疗程均为3个月。结果 试验组总有效率高于对照组,差异具有统计学意义,P <0.05。2组均有效降低中医证候积分,改善Harris髋关节评分和疼痛VAS评分,增加周围静脉血中BMP-2、VEGF含量。经统计学分析,试验组均优于对照组P <0.05,且均未见不良反应。结论 骨坏死康复丸治疗股骨头坏死肝肾亏虚证疗效显著,可以有效改善髋关节功能、缓解疼痛,并能增加血液中BMP-2和VEGF含量。
Objective To investigate the clinical effect of Guhuaisi Kangfu pill in the treatment of femoral head necrosis with deficiency of liver and kidney. Methods 80 cases of osteonecrosis of the femoral head of liver and kidney deficiency syndrome were randomly divided into experimental group and control group,with 40 cases in each group. The experimental group took Guhuaisi Kangfu pill and the control group took Xianling Gubao capsule. The treatment course was 3 months. Results The effective rate of the experimental group and the effective rate of the control group and the difference was statistically significant(P < 0. 05). Both groups can effectively reduce traditional Chinese medicine syndrome score,improve Harris hip score and pain VAS score,and increase the content of BMP-2 and VEGF in peripheral vein blood. The results showed that the experimental group was better than the control group(P < 0. 05),and no adverse reactions were found. Conclusion Guhuaisi Kangfu pill has a significant effect on the treatment of osteonecrosis of femoral head in the deficiency of liver and kidney,which can effectively improve the function of hip joint and relieve pain,and increase the BMP-2 and VEGF content in blood.
作者
崔朋涛
周志锋
刘子嘉
李文茜
曹玉举
CUI Pengtao;ZHOU Zhifeng;LIU Zijia;LI Wenxi;CAO Yuju(Osteoarthrology Department,Zhengzhou Orthopedics Hospital of Traditional Chinese Medicine,Henan Province,Zhengzhou 450016,China;The Second Clinical Medical College,Henan University of Traditional Chinese Medicine,Henan Province,Zhengzhou 450046,China)
出处
《光明中医》
2022年第18期3325-3329,共5页
GUANGMING JOURNAL OF CHINESE MEDICINE
基金
河南省中医药科学研究专项课题(No.2018ZY30112)
河南省中医药重点实验室建设项目(No.豫卫中医函[2021]30号)
郑州市工程技术研究中心和重点实验室项目(No.郑科[2020]34号)。
关键词
骨蚀
骨坏死康复丸
股骨头坏死
肝肾亏虚证
erosion of bone
Guhuaisi Kangfu pill
osteonecrosis of the femoral head
Deficiency of Liver and Kidney