强直性脊柱炎患者血清中MMP-9、S100A12及CRP水平变化及临床意义

Changes and clinical significance of serum MMP-9,S100A12 and CRP in patients with ankylosing spondylitis

目的 探讨血清中MMP-9、S100A12及CRP水平与强直性脊柱炎(ankylosing spondylitis,AS)之间的联系,为AS的诊治提供临床依据。方法 选取2017年6月~2019年10月在我院接受治疗的122例AS患者为观察组,选取同时期122例健康体检者为对照组,对受试者血清中的MMP-9、S100A12及CRP水平进行测定并进行比较。结果 观察组患者血清中MMP-9、S100A12及CRP水平明显高于对照组(P<0.05);BASDAI≥5分组中的患者血清MMP-9、S100A12及CRP水平明显偏高(P<0.05);BASFI≥5分组中的患者血清MMP-9、S100A12及CRP水平明显偏高(P<0.05)。结论 AS患者血清中MMP-9、S100A12及CRP均异常表达,且与病情联系密切,可依据血清中相关指标变化对病情进行评估。

Objective To investigate the relationship between serum MMP-9,S100 A12 and CRP levels and ankylosing spondylitis(AS),so as to provide clinical basis for the diagnosis and treatment of AS.Methods From June 2017 to October 2019,122 AS patients who were treated in our hospital were selected as the observation group,and 122 healthy persons in the same period were selected as the control group.The levels of MMP-9,S100 A12 and CRP in the serum of patients were measured and compared.Results The levels of MMP-9,S100 A12 and CRP in the observation group were significantly higher than those in the control group(P<0.05).The contents of MMP-9,S100 A12 and CRP in patients with BASDAI≥5 group were significantly higher than those in the control group(P<0.05).The contents of MMP-9,S100 A12 and CRP in patients with BASFI≥5 group were significantly higher than those in the control group(P<0.05).Conclusions The abnormal expression of MMP-9,S100 A12 and CRP in the serum of AS patients is closely related to the disease.The disease can be evaluated according to the changes of relevant indicators in serum.